The salts of alpha-ketogluterate (calcium, magnesium, and potassium) have been demonstrated to increase muscle-glutamine stores in severely catabolic hospital patients to a greater degree than leucine. Alpha-Ketogluterate is utilized in the Krebs cycle and provides the carbon skeleton for a portion of glutamine synthesis. The combination of leucine and salts of alpha-ketoglutarate can provide invaluable support for both muscle metabolism and immune functions during the periods of stress.
The combination of KIC, leucine and salts of alpha-ketogluterate can produce measurable anabolic effects. The strong anticatabolic effects produced by the combination of KIC, alpha-ketogluterate and leucine can limit the uses of amino acids for energy and promote the use of fatty acids, resulting in decreased urine-urea nitrogen.
It is reasonable to assume that this combination of nutrients could eventually lead to increased lean mass and decreased body fat, provided that appropriate diet and training procedures are followed.